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The disease was first described in 1891 by Guido Werdnig (1844-1919). Presents with hypotonia in infancy, with weakness in the limb, intercostal and bulbar muscles. This reflex was documented in 1911 by his student Hans Curschmann (1875-1950). Hoffmann discussed this reflex in his teaching and used it in clinical practice, but never published. Sudden release of the flexed distal phalanx of the second, third, or fourth digits leads to flexion of the terminal phalanx of the thumb and of the last two interphalangeal joints of other fingers of that hand in the case of pyramidal tract disease affecting that limb. The ‘Hoffmann reflex’ refers to the finger reflex for hyper-reflexia associated with upper motor neuron lesions.
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1919 – Full professor of neuropathology.Assistant to Wilhelm Erb in the division of neurology.Many clinical contributions to neurology include his differentiation of myotonic dystrophy and myotonia congenita the Hoffmann reflex and an accurate description of hereditary motor neuropathy type 1, acknowledging the previous report of Werdnig (Werdnig-Hoffmann syndrome) Biography Hoffmann’s interests centred on the spinaI cord and neuromuscular system and he continued the process of differentiation and delineation of the neuromyopathies which had been initiated by his mentors Nikolaus Friedreich (1825 – 1882) Wilhelm Heinrich Erb (1840 – 1921). Widely regarded as the first ‘pure’ neurologist in Germany Johann Hoffmann (1857 – 1919) was a German neurologist.